Immune response to influenza A (H1N1)v monovalent MF59-adjuvanted vaccine in HIV-infected patients.

Authors :: Fabbiani M
Di Giambenedetto S
Sali M
Farina S
Sansonetti P
Tamburrini E
Dal Verme LZ
Delogu G
De Luca A
Kelvin D
Cauda R
Fadda G
Source :: Vaccine [Vaccine] 2011 Apr 05; Vol. 29 (16), pp. 2836-9. Date of Electronic Publication: 2011 Feb 22.
Publication Year :: 2011
Abstract: Immunogenicity of influenza A (H1N1)v MF59-adjuvanted vaccine was studied in HIV-infected patients. The vaccine was effective in inducing a protective immune response in patients with a CD4 >200 cells/μL while individuals with CD4 <200 cells/μL showed lower rates of seroconversion and seroprotection. These results underscore the usefulness of immunization against influenza in HIV-infected patients, though a boosting dose of vaccine may be required in seriously immunocompromised patients.<br /> (Copyright © 2011 Elsevier Ltd. All rights reserved.)

Subjects :: Adjuvants, Immunologic pharmacology
Adult
Antibodies, Viral blood
CD4 Lymphocyte Count
Female
HIV immunology
Humans
Influenza A Virus, H1N1 Subtype immunology
Male
Middle Aged
Polysorbates pharmacology
Squalene pharmacology
HIV Infections immunology
Hemagglutinin Glycoproteins, Influenza Virus immunology
Influenza Vaccines immunology
Influenza, Human prevention & control

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