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Protection of flunarizine on cerebral mitochondria injury induced by cortical spreading depression under hypoxic conditions.
- Source :
-
The journal of headache and pain [J Headache Pain] 2011 Feb; Vol. 12 (1), pp. 47-53. Date of Electronic Publication: 2011 Feb 25. - Publication Year :
- 2011
-
Abstract
- A rat cortical spreading depression (CSD) model was established to explore whether cerebral mitochondria injury was induced by CSD under both normoxic and hypoxic conditions and whether flunarizine had a protective effect on cerebral mitochondria. SD rats, which were divided into seven groups, received treatment as follows: no intervention (control Group I); 1 M NaCl injections (Group II); 1 M KCl injections (Group III); intraperitoneal flunarizine (3 mg/kg) 30 min before KCl injections (Group IV); 14% O(2) inhalation before NaCl injections (Group V); 14% O(2) inhalation followed by KCl injections (Group VI); 14% O(2) inhalation and intraperitoneal flunarizine followed by KCl injections (Group VII). Following treatment, brains were removed for the analysis of mitochondria transmembrane potential (MMP) and oxidative respiratory function after recording the number, amplitude and duration of CSD. The duration of CSD was significantly longer in Group VI than that in Group III. The number and duration of CSD in Group VII was significantly lower than that in Group VI. MMP in Group VI was significantly lower than that in Group III, and MMP in Group VII was significantly higher than that in Group VI. State 4 respiration in Group VI was significantly higher than that in Group III, and state 3 respiration in Group VII was significantly higher than that in Group VI. Respiration control of rate in Group VII was also significantly higher than that in Group VI. Thus, we concluded that aggravated cerebral mitochondria injury might be attributed to CSD under hypoxic conditions. Flunarizine can alleviate such cerebral mitochondria injury under both normoxic and hypoxic conditions.
- Subjects :
- Animals
Cortical Spreading Depression physiology
Disease Models, Animal
Hypoxia, Brain pathology
Hypoxia, Brain physiopathology
Male
Migraine Disorders physiopathology
Mitochondrial Diseases pathology
Mitochondrial Diseases physiopathology
Rats
Rats, Sprague-Dawley
Cortical Spreading Depression drug effects
Flunarizine pharmacology
Hypoxia, Brain drug therapy
Migraine Disorders drug therapy
Migraine Disorders pathology
Mitochondrial Diseases prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1129-2377
- Volume :
- 12
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The journal of headache and pain
- Publication Type :
- Academic Journal
- Accession number :
- 21350793
- Full Text :
- https://doi.org/10.1007/s10194-011-0300-1