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The role of recombination for the coevolutionary dynamics of HIV and the immune response.
- Source :
-
PloS one [PLoS One] 2011 Feb 18; Vol. 6 (2), pp. e16052. Date of Electronic Publication: 2011 Feb 18. - Publication Year :
- 2011
-
Abstract
- The evolutionary implications of recombination in HIV remain not fully understood. A plausible effect could be an enhancement of immune escape from cytotoxic T lymphocytes (CTLs). In order to test this hypothesis, we constructed a population dynamic model of immune escape in HIV and examined the viral-immune dynamics with and without recombination. Our model shows that recombination (i) increases the genetic diversity of the viral population, (ii) accelerates the emergence of escape mutations with and without compensatory mutations, and (iii) accelerates the acquisition of immune escape mutations in the early stage of viral infection. We see a particularly strong impact of recombination in systems with broad, non-immunodominant CTL responses. Overall, our study argues for the importance of recombination in HIV in allowing the virus to adapt to changing selective pressures as imposed by the immune system and shows that the effect of recombination depends on the immunodominance pattern of effector T cell responses.
- Subjects :
- Antigenic Variation genetics
Antigenic Variation immunology
Antigenic Variation physiology
Computer Simulation
Genetic Variation immunology
HIV Infections genetics
HIV Infections virology
Humans
Immune Evasion genetics
Models, Biological
Models, Theoretical
Mutation physiology
Time Factors
Adaptive Immunity genetics
Evolution, Molecular
HIV genetics
HIV immunology
HIV Infections immunology
Recombination, Genetic physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 6
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 21364750
- Full Text :
- https://doi.org/10.1371/journal.pone.0016052