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Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han population.
- Source :
-
Nature genetics [Nat Genet] 2011 Mar 06; Vol. 43 (4), pp. 345-9. Date of Electronic Publication: 2011 Mar 06. - Publication Year :
- 2011
-
Abstract
- Coronary artery disease (CAD) causes more than 700,000 deaths each year in China. Previous genome-wide association studies (GWAS) in populations of European ancestry identified several genetic loci for CAD, but no such study has yet been reported in the Chinese population. Here we report a three-stage GWAS in the Chinese Han population. We identified a new association between rs6903956 in a putative gene denoted as C6orf105 on chromosome 6p24.1 and CAD (P = 5.00 × 10⁻³, stage 2 validation; P = 3.00 × 10⁻³, P = 1.19 × 10⁻⁸ and P = 4.00 × 10⁻³ in three independent stage 3 replication populations; P = 4.87 × 10⁻¹², odds ratio = 1.51 in the combined population). The minor risk allele A of rs6903956 is associated with decreased C6orf105 mRNA expression. We report the first GWAS for CAD in the Chinese Han population and identify a SNP, rs6903956, in C6orf105 associated with susceptibility to CAD in this population.
- Subjects :
- Alleles
Case-Control Studies
China
Chromosomes, Human, Pair 6 genetics
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Linkage Disequilibrium
Male
Polymorphism, Single Nucleotide
RNA, Messenger genetics
Risk Factors
Asian People genetics
Coronary Artery Disease genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1546-1718
- Volume :
- 43
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Nature genetics
- Publication Type :
- Academic Journal
- Accession number :
- 21378986
- Full Text :
- https://doi.org/10.1038/ng.783