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Transformation of anionically activated trifluoromethyl groups to heterocycles under mild aqueous conditions.
- Source :
-
Organic letters [Org Lett] 2011 Apr 01; Vol. 13 (7), pp. 1804-7. Date of Electronic Publication: 2011 Mar 07. - Publication Year :
- 2011
-
Abstract
- The (hetero)aromatic trifluoromethyl group is present in many biologically active molecules and is generally considered to be chemically stable. In this paper, a convenient one-step synthesis of C-C linked aryl-heterocycles or heteroaryl-heterocycles in good to excellent yields via the reaction of anionically activated trifluoromethyl groups with amino nucleophiles containing a second NH, OH, or SH nucleophile in 1 N sodium hydroxide is reported. The method has high functional group tolerability and is potentially useful in parallel synthesis.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 13
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 21381681
- Full Text :
- https://doi.org/10.1021/ol200326u