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Synthesis of (-)-homogalanthamine from naltrexone.
- Source :
-
The Journal of organic chemistry [J Org Chem] 2011 Apr 01; Vol. 76 (7), pp. 2257-60. Date of Electronic Publication: 2011 Mar 07. - Publication Year :
- 2011
-
Abstract
- Acetylcholinesterase inhibitor (-)-homogalanthamine 3 was synthesized from μ opioid antagonist naltrexone (2) in 16% total yield. The synthesis features Grob fragmentation as a key reaction, which was especially accelerated in the presence of 15-crown-5.
- Subjects :
- Magnetic Resonance Spectroscopy
Molecular Structure
Crown Ethers chemistry
Galantamine chemical synthesis
Galantamine chemistry
Naltrexone chemical synthesis
Naltrexone chemistry
Narcotic Antagonists chemical synthesis
Narcotic Antagonists chemistry
Receptors, Opioid, mu antagonists & inhibitors
Receptors, Opioid, mu chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1520-6904
- Volume :
- 76
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- The Journal of organic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 21381712
- Full Text :
- https://doi.org/10.1021/jo1022487