Impact of IL-18 on inflammation.

Authors :: Tripodi D
Maccauro G
Anogeianaki A
Castellani ML
Pandolfi F
Felaco P
Toniato E
De Lutiis MA
Fulcheri M
Tetè S
Galzio R
Salini V
Caraffa A
Antinolfi P
Frydas I
Sabatino G
Shaik-Dasthagirisaheb YB
Source :: Journal of biological regulators and homeostatic agents [J Biol Regul Homeost Agents] 2011 Jan-Mar; Vol. 25 (1), pp. 7-11.
Publication Year :: 2011
Abstract: IL-18 is produced by many cell types, such as Kupffer cells, keratinocytes, macrophages, dendritic cells, and activated T cells stimulated by LPS. It is an important regulator of both innate and acquired immune responses. IL-18 plays a central role in rheumatoid arthritis since the T cells and macrophages that invade the synovial. These finding support a role for IL-18 in inflammation, allergy and immune diseases.