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Amyloid deposition in 2 feline thymomas.
- Source :
-
Veterinary pathology [Vet Pathol] 2012 Jul; Vol. 49 (4), pp. 616-20. Date of Electronic Publication: 2011 Mar 07. - Publication Year :
- 2012
-
Abstract
- Two cases of feline thymoma with amyloid deposition were encountered between 1982 and 2010. Neoplastic cells were separated by abundant, pale eosinophilic, homogeneous material that was congophilic and birefringent. Ultrastructurally, the neoplastic cells were connected by desmosomes, and the extracellular deposits were composed of nonbranching, hollow-cored fibrils, 8-10 nm in diameter. In the case with sufficient archived tissue for additional sections, the amyloid remained congophilic following potassium permanganate incubation, and the neoplastic cells were immunoreactive for pancytokeratin. The histologic, histochemical, ultrastructural, and immunohistochemical features of both neoplasms are consistent with epithelial-predominant thymoma with the unusual feature of intratumoral amyloid deposition. The affinity of the amyloid for Congo red following potassium permanganate incubation is consistent with non-AA amyloid. The ultrastructural findings were consistent with amyloid production by the neoplastic epithelial cells.
- Subjects :
- Animals
Cat Diseases metabolism
Cats
Female
Immunosuppressive Agents therapeutic use
Male
Mediastinal Neoplasms metabolism
Mediastinal Neoplasms pathology
Prednisone therapeutic use
Retrospective Studies
Thymoma metabolism
Thymoma pathology
Amyloid metabolism
Cat Diseases pathology
Mediastinal Neoplasms veterinary
Thymoma veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 1544-2217
- Volume :
- 49
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Veterinary pathology
- Publication Type :
- Academic Journal
- Accession number :
- 21383114
- Full Text :
- https://doi.org/10.1177/0300985811400442