A 4-[(3R,4R)-dihydroxypyrrolidino]pyrimidin-2-one nucleobase for a CG base pair in triplex DNA.

Authors :: Hari Y
Akabane M
Hatanaka Y
Nakahara M
Obika S
Source :: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2011 Apr 21; Vol. 47 (15), pp. 4424-6. Date of Electronic Publication: 2011 Mar 09.
Publication Year :: 2011
Abstract: In order to expand target sequences in triplex DNA formation, the development of a nucleobase that recognizes a CG base pair in dsDNA was attempted. A 4-[(3R,4R)-dihydroxypyrrolidino]pyrimidin-2-one nucleobase was found to recognize a CG base pair with high sequence-selectivity.<br /> (© The Royal Society of Chemistry 2011)

Subjects :: Base Sequence
DNA genetics
Nucleic Acid Denaturation
Oligodeoxyribonucleotides chemical synthesis
Oligodeoxyribonucleotides chemistry
Oligodeoxyribonucleotides genetics
Substrate Specificity
Transition Temperature
Base Pairing
DNA chemistry
Pyrimidinones chemistry

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