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Antioxidant responses, hepatic intermediary metabolism, histology and ultrastructure in Synechogobius hasta exposed to waterborne cadmium.
- Source :
-
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2011 Jul; Vol. 74 (5), pp. 1156-63. Date of Electronic Publication: 2011 Mar 09. - Publication Year :
- 2011
-
Abstract
- The present study was conducted to determine antioxidant responses, hepatic intermediary metabolism, histology and ultrastructure in Synechogobius hasta after a 15-days of waterborne cadmium (Cd) exposure at the concentrations of 0 (control), 0.10, 0.17 and 0.29 mg Cd/l (corresponding to 0, 12.6%, 21.5% and 36.7% of 96 h LC₅₀), respectively. Growth performance and survival declined, but hepatosomatic index (HSI) increased with increasing waterborne Cd levels (P < 0.05). Waterborne Cd exposure also significantly increased lipid contents in whole body and liver (P < 0.05), and Cd accumulation in whole body, muscle and vertebrae. Waterborne Cd exposure changed hepatic enzymatic activities involved in intermediary metabolism, induced antioxidant responses and increased lipid peroxidation level in the gill, liver and spleen. Waterborne Cd exposure also caused considerable histological alterations of gill, liver and spleen, led ultrastructures damage of liver and spleen of fish, and induced fatty liver for this fish species.<br /> (Copyright © 2011 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Antioxidants metabolism
Cadmium metabolism
Calcium metabolism
Gills metabolism
Gills pathology
Hepatocytes drug effects
Hepatocytes pathology
Hepatocytes ultrastructure
Lipid Peroxidation drug effects
Liver drug effects
Liver pathology
Protein Carbonylation drug effects
Spleen drug effects
Spleen pathology
Spleen ultrastructure
Water Pollutants, Chemical metabolism
Cadmium toxicity
Chemical and Drug Induced Liver Injury metabolism
Liver metabolism
Perciformes metabolism
Water Pollutants, Chemical toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2414
- Volume :
- 74
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Ecotoxicology and environmental safety
- Publication Type :
- Academic Journal
- Accession number :
- 21392825
- Full Text :
- https://doi.org/10.1016/j.ecoenv.2011.02.015