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Neuronal voltage-gated potassium channel complex autoimmunity in children.
- Source :
-
Pediatric neurology [Pediatr Neurol] 2011 Apr; Vol. 44 (4), pp. 275-81. - Publication Year :
- 2011
-
Abstract
- Autoimmunity targeting voltage-gated potassium channel complexes have not been systematically documented in children. Identified in the Neuroimmunology Laboratory records of Mayo Clinic were 12 seropositive children, 7 among 252 Mayo Clinic pediatric patients tested on a service basis for serologic evidence of neurologic autoimmunity (June 2008-April 2010), 4 during the assay's preimplementation validation (before June 2008) and 1 non-Mayo patient with available clinical information. Neurologic manifestations were subacute and multifocal. Three had global developmental regression, 6 movement disorders, 4 dysarthria, 3 seizures, 1 Satoyoshi syndrome, 1 painful red feet, 2 insomnia, 2 gastrointestinal dysmotility, and 2 small fiber neuropathy. Neoplasia was found in 1 child. Treating physicians recorded improvement in all 7 children who received immunotherapy. Neurologic symptom relapse occurred in 3 of 6 children after ceasing immunotherapy. These findings highlight a diverse clinical spectrum of neuronal potassium channel complex autoimmunity in children, and they illustrate benefit from early initiated immunotherapy, with a tendency to relapse when therapy ceases. Diagnosis is generally delayed in the process of eliminating neurodegenerative causes. Currently 2.7% of pediatric sera evaluated for neurologic autoimmunity are positive for neuronal potassium channel complex-reactive immunoglobulin G. The frequency and full spectrum of neurologic accompaniments remains to be determined.<br /> (Copyright © 2011 Elsevier Inc. All rights reserved.)
- Subjects :
- Adolescent
Autoimmune Diseases immunology
Child
Child, Preschool
Female
Humans
Immunoglobulin G blood
Immunoprecipitation methods
Immunosuppressive Agents therapeutic use
Magnetic Resonance Imaging
Male
Neoplasms etiology
Plasma Exchange methods
Autoantibodies blood
Autoimmune Diseases blood
Autoimmune Diseases therapy
Autoimmunity immunology
Potassium Channels, Voltage-Gated immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-5150
- Volume :
- 44
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Pediatric neurology
- Publication Type :
- Academic Journal
- Accession number :
- 21397169
- Full Text :
- https://doi.org/10.1016/j.pediatrneurol.2010.10.015