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Role of curcumin-dependent modulation of tumor microenvironment of a murine T cell lymphoma in altered regulation of tumor cell survival.
- Source :
-
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2011 May 01; Vol. 252 (3), pp. 298-306. Date of Electronic Publication: 2011 Mar 11. - Publication Year :
- 2011
-
Abstract
- Using a murine model of a T cell lymphoma, in the present study, we report that tumor growth retarding action of curcumin involves modulation of some crucial parameters of tumor microenvironment regulating tumor progression. Curcumin-administration to tumor-bearing host caused an altered pH regulation in tumor cells associated with alteration in expression of cell survival and apoptosis regulatory proteins and genes. Nevertheless, an alteration was also observed in biophysical parameters of tumor microenvironment responsible for modulation of tumor growth pertaining to hypoxia, tumor acidosis, and glucose metabolism. The study thus sheds new light with respect to the antineoplastic action of curcumin against a tumor-bearing host with progressively growing tumor of hematological origin. This will help in optimizing application of the drug and anticancer research and therapy.<br /> (Copyright © 2011 Elsevier Inc. All rights reserved.)
- Subjects :
- ATP Binding Cassette Transporter, Subfamily B biosynthesis
ATP Binding Cassette Transporter, Subfamily B genetics
Animals
Apoptosis drug effects
Apoptosis Regulatory Proteins biosynthesis
Apoptosis Regulatory Proteins genetics
Cell Growth Processes drug effects
Female
Glucose Transport Proteins, Facilitative biosynthesis
Glucose Transport Proteins, Facilitative genetics
HSP70 Heat-Shock Proteins biosynthesis
HSP70 Heat-Shock Proteins genetics
Hypoxia-Inducible Factor 1, alpha Subunit biosynthesis
Hypoxia-Inducible Factor 1, alpha Subunit genetics
Lymphoma, T-Cell genetics
Lymphoma, T-Cell metabolism
Lymphoma, T-Cell pathology
Male
Mice
Mice, Inbred BALB C
Proto-Oncogene Proteins c-bcl-2 biosynthesis
Proto-Oncogene Proteins c-bcl-2 genetics
RNA, Messenger biosynthesis
RNA, Messenger genetics
Reverse Transcriptase Polymerase Chain Reaction
Specific Pathogen-Free Organisms
Survival Analysis
Tumor Microenvironment drug effects
Tumor Suppressor Proteins biosynthesis
Tumor Suppressor Proteins genetics
Vascular Endothelial Growth Factor A biosynthesis
Vascular Endothelial Growth Factor A genetics
Antineoplastic Agents pharmacology
Curcumin pharmacology
Lymphoma, T-Cell drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1096-0333
- Volume :
- 252
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Toxicology and applied pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 21397623
- Full Text :
- https://doi.org/10.1016/j.taap.2011.03.002