Antimicrobial peptoids are effective against Pseudomonas aeruginosa biofilms.

Authors :: Kapoor R
Wadman MW
Dohm MT
Czyzewski AM
Spormann AM
Barron AE
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2011 Jun; Vol. 55 (6), pp. 3054-7. Date of Electronic Publication: 2011 Mar 21.
Publication Year :: 2011
Abstract: The resistance of biofilms to conventional antibiotics complicates the treatment of chronic cystic fibrosis (CF). We investigated the effects of peptoids, peptides, and conventional antibiotics on the biomass and cell viability within Pseudomonas aeruginosa biofilms. At their MICs, peptoids 1 and 1-C13(4mer) caused maximum reductions in biomass and cell viability, respectively. These results suggest that peptoids of this class could be worth exploring for the treatment of pulmonary infections occurring in CF patients.