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Raltegravir concentrations in the genital tract of HIV-1-infected women treated with a raltegravir-containing regimen (DIVA 01 study).
- Source :
-
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2011 Jun; Vol. 55 (6), pp. 3018-21. Date of Electronic Publication: 2011 Mar 28. - Publication Year :
- 2011
-
Abstract
- We studied the penetration of raltegravir and HIV shedding in the genital tract among 14 HIV-1-infected women receiving a raltegravir-containing regimen who had <40 copies/ml blood plasma (BP) HIV RNA. None of the cervicovaginal fluid (CVF) samples showed detectable HIV RNA. Median raltegravir concentrations were 235 ng/ml in BP and 93 ng/ml in CVF, with a CVF/BP ratio of approximately 2.3. This good penetration of raltegravir may contribute to the control of viral replication in the female genital tract.
Details
- Language :
- English
- ISSN :
- 1098-6596
- Volume :
- 55
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Antimicrobial agents and chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 21444705
- Full Text :
- https://doi.org/10.1128/AAC.01460-10