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Decades of delayed diagnosis in 4 levodopa-responsive young-onset monogenetic parkinsonism patients.
- Source :
-
Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2011 Jun; Vol. 26 (7), pp. 1337-40. Date of Electronic Publication: 2011 Mar 29. - Publication Year :
- 2011
-
Abstract
- Background: We report 4 patients with young-onset monogenetic parkinsonism, each of whom was misdiagnosed with either a psychogenic movement disorder or chronic fatigue syndrome for 10 to 23 years after the onset of their first symptoms.<br />Results: Once the diagnosis was eventually made, they all had a rapid and excellent response to levodopa, albeit with the early appearance of interdose dyskinesias in 3.<br />Conclusions: We discuss possible reasons for the missed diagnosis despite the relentless progression of their motor handicap. DAT scanning supported the revised clinical diagnosis of parkinsonism. © 2011 Movement Disorder Society.<br /> (Copyright © 2011 Movement Disorder Society.)
- Subjects :
- Adult
Age of Onset
Diagnosis, Differential
Dystonic Disorders diagnosis
Fatigue Syndrome, Chronic diagnosis
Female
Gait Disorders, Neurologic diagnosis
Humans
Parkinsonian Disorders genetics
Time Factors
Young Adult
Antiparkinson Agents therapeutic use
Delayed Diagnosis
Levodopa therapeutic use
Parkinsonian Disorders diagnosis
Parkinsonian Disorders drug therapy
Ubiquitin-Protein Ligases genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1531-8257
- Volume :
- 26
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Movement disorders : official journal of the Movement Disorder Society
- Publication Type :
- Academic Journal
- Accession number :
- 21449012
- Full Text :
- https://doi.org/10.1002/mds.23563