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[Comparative sensitivity of liver monoamine oxidases of frog and whitefish to some tricyclic compounds].
- Source :
-
Zhurnal evoliutsionnoi biokhimii i fiziologii [Zh Evol Biokhim Fiziol] 2011 Jan-Feb; Vol. 47 (1), pp. 21-6. - Publication Year :
- 2011
-
Abstract
- There is performed a comparative analysis of action of four acridine derivatives and of one xanthene derivative (pyronine G) on activity of liver monoamine oxidase (MAO) of two species of poikilothermal freshwater animals: a representative of amphibians--the common frog Rana temnporaria and a representative of the order Salmonidae--the European whitefish Coregonus lavaretus. The studied synthetic hexamerous tricyclic compounds show the irreversible character of inhibition of intermediate potency towards the enzyme from both biological sources. There are obtained qualitative and quantitative differences in the reactional ability and selectivity of action of the studied inhibitors for liver MAO of frog and whitefish. The obtained data of the inhibitory analysis with use of specific substrates are an indirect proof for the existence in liver of the studies frog species of two molecular forms, whereas in the whitefish liver--single molecular MAO form.
- Subjects :
- Acridine Orange pharmacology
Animals
Male
Monoamine Oxidase chemistry
Proflavine pharmacology
Pyronine pharmacology
Tacrine pharmacology
Liver enzymology
Mitochondria, Liver enzymology
Monoamine Oxidase metabolism
Monoamine Oxidase Inhibitors pharmacology
Rana temporaria metabolism
Salmonidae metabolism
Subjects
Details
- Language :
- Russian
- ISSN :
- 0044-4529
- Volume :
- 47
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Zhurnal evoliutsionnoi biokhimii i fiziologii
- Publication Type :
- Academic Journal
- Accession number :
- 21469337
- Full Text :
- https://doi.org/10.1134/s0022093011010038