Prevalence of Helicobacter pylori genotypes (vacA, cagA, cagE and virB11) in gastric cancer in Brazilian's patients: an association with histopathological parameters.

Authors :: Lima VP
Silva-Fernandes IJ
Alves MK
Rabenhorst SH
Source :: Cancer epidemiology [Cancer Epidemiol] 2011 Oct; Vol. 35 (5), pp. e32-7. Date of Electronic Publication: 2011 Apr 05.
Publication Year :: 2011
Abstract: Purpose: To investigate the frequency and the association of vacA alleles, cagA, cagE and virB11 genes of Helicobacter pylori from patients with gastric cancer, considering the clinic histopathological parameters.<br />Methods: One hundred and one gastric adenocarcinoma tissues were assessed by PCR to detect H. pylori and vacA alleles, cagA, cagE and virB11.<br />Results: The distribution of cases according to the presence of the genes studied showed that the group containing vacA s1m1, cagA, cagE and virB11 H. pylori genes was significantly more frequent, followed by the group with at least one marker on the right side and left of the island. They were also present in the early stages and were the most frequent in nearly all histopathological grades.<br />Conclusions: This study verified that vacAs1m1 and cag-PAI genes, cagA, cagE and virB11 are important H. pylori markers for gastric cancer development. Also, this study corroborates the importance of cagE and cagA together as cag-PAI marker.<br /> (Copyright © 2011 Elsevier Ltd. All rights reserved.)

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