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Effects of verbascoside, biotechnologically purified by Syringa vulgaris plant cell cultures, in a rodent model of periodontitis.
- Source :
-
The Journal of pharmacy and pharmacology [J Pharm Pharmacol] 2011 May; Vol. 63 (5), pp. 707-17. Date of Electronic Publication: 2011 Apr 01. - Publication Year :
- 2011
-
Abstract
- Objectives: Verbascoside has previously been characterized as an effective scavenger of active free radicals and an inhibitor of lipid peroxidation. In the present study, we have investigated the effects of verbascoside from Syringa vulgaris in a rat model of ligature-induced periodontitis.<br />Methods: Male Sprague-Dawley rats were lightly anaesthetized with pentobarbitone (35 mg/kg). Sterile, 2-0 black braided silk thread was placed around the cervix of the lower left first molar and knotted medially. Animals received vebascoside 2 mg/kg orally, daily for 8 days.<br />Key Findings: On the eighth day after placement of the ligature, we evaluated several markers of inflammation: (i) myeloperoxidase activity, (ii) thiobarbituric acid-reactant substance measurements, (iii) NF-κB expression, (iv) iNOS expression, (v) the nitration of tyrosine residues, (vi) activation of the nuclear enzyme poly(ADP-ribose) polymerase, (vii) Bax and Bcl-2 expression and (viii) a degree of gingivomucosal tissue injury. Oral administration of verbascoside (2 mg/kg daily for 8 days) significantly decreased all of the parameters of inflammation as described above.<br />Conclusions: These results demonstrate that verbascoside exerts an anti-inflammatory role during experimental periodontitis and is able to ameliorate the tissue damage associated with ligature-induced periodontitis.<br /> (© 2011 The Authors. JPP © 2011 Royal Pharmaceutical Society.)
- Subjects :
- Animals
Anti-Inflammatory Agents isolation & purification
Anti-Inflammatory Agents pharmacology
Antioxidants isolation & purification
Antioxidants pharmacology
Antioxidants therapeutic use
Biomarkers metabolism
Cells, Cultured
Disease Models, Animal
Gingiva drug effects
Gingiva pathology
Glucosides isolation & purification
Glucosides pharmacology
Ligation
Male
Molar
Mouth Mucosa drug effects
Mouth Mucosa pathology
Periodontitis metabolism
Periodontitis pathology
Phenols isolation & purification
Phenols pharmacology
Plant Extracts chemistry
Plant Extracts pharmacology
Rats
Rats, Sprague-Dawley
Anti-Inflammatory Agents therapeutic use
Glucosides therapeutic use
Inflammation Mediators metabolism
Periodontitis drug therapy
Phenols therapeutic use
Phytotherapy
Plant Extracts therapeutic use
Syringa chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 2042-7158
- Volume :
- 63
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The Journal of pharmacy and pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 21492173
- Full Text :
- https://doi.org/10.1111/j.2042-7158.2011.01262.x