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Pharmacokinetics of oseltamivir according to trimester of pregnancy.
- Source :
-
American journal of obstetrics and gynecology [Am J Obstet Gynecol] 2011 Jun; Vol. 204 (6 Suppl 1), pp. S89-93. Date of Electronic Publication: 2011 Mar 09. - Publication Year :
- 2011
-
Abstract
- The purpose of this study was to determine pharmacokinetic parameters for oseltamivir in all trimesters of pregnancy. Thirty pregnant women, 10 per trimester, who were receiving oseltamivir phosphate (75 mg) were recruited to study first-dose pharmacokinetics. Plasma samples were obtained at 0, 0.5, 1, 2, 4, 8, and 12 hours after the first dose. Samples were analyzed for oseltamivir and oseltamivir carboxylate levels. With the use of a noncompartmental model, we estimated the area-under-the-curve, maximum concentration, time-to-maximum concentration, and half-life. There were no significant differences in the pharmacokinetics of oseltamivir by trimester, except for an increased half-life in the first trimester for oseltamivir phosphate and an increased maximum concentration in the third trimester for oseltamivir carboxylate. The levels of oseltamivir carboxylate that were observed were within the range that was needed to achieve inhibitory concentrations at 50% for pandemic H1N1. The pharmacokinetics of oseltamivir does not change significantly according to trimester of pregnancy.<br /> (Copyright © 2011 Mosby, Inc. All rights reserved.)
- Subjects :
- Adolescent
Adult
Antiviral Agents blood
Area Under Curve
Female
Half-Life
Humans
Influenza A virus
Influenza B virus
Influenza, Human blood
Influenza, Human epidemiology
Maximum Allowable Concentration
Oseltamivir analogs & derivatives
Oseltamivir blood
Pandemics
Pregnancy
Pregnancy Complications, Infectious blood
Pregnancy Complications, Infectious epidemiology
Time Factors
Young Adult
Antiviral Agents pharmacokinetics
Influenza A Virus, H1N1 Subtype
Influenza, Human drug therapy
Oseltamivir pharmacokinetics
Pregnancy Complications, Infectious drug therapy
Pregnancy Trimesters blood
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6868
- Volume :
- 204
- Issue :
- 6 Suppl 1
- Database :
- MEDLINE
- Journal :
- American journal of obstetrics and gynecology
- Publication Type :
- Academic Journal
- Accession number :
- 21492824
- Full Text :
- https://doi.org/10.1016/j.ajog.2011.03.005