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Total synthesis and biological evaluation of marinopyrrole A and analogues.

Authors :
Nicolaou KC
Simmons NL
Chen JS
Haste NM
Nizet V
Source :
Tetrahedron letters [Tetrahedron Lett] 2011 Apr 27; Vol. 52 (17), pp. 2041-2043.
Publication Year :
2011

Abstract

A five-step total synthesis of the antibiotic marinopyrrole A (1) is described. The developed synthetic technology enabled the synthesis of several marinopyrrole A analogues whose antibacterial properties against methicillin-resistant Staphylococcus aureus TCH1516 were evaluated.

Details

Language :
English
ISSN :
0040-4039
Volume :
52
Issue :
17
Database :
MEDLINE
Journal :
Tetrahedron letters
Publication Type :
Academic Journal
Accession number :
21499535
Full Text :
https://doi.org/10.1016/j.tetlet.2010.09.059