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PML as a potential predictive factor of oxaliplatin/fluoropyrimidine-based first line chemotherapy efficacy in colorectal cancer patients.
- Source :
-
Journal of cellular physiology [J Cell Physiol] 2012 Mar; Vol. 227 (3), pp. 927-33. - Publication Year :
- 2012
-
Abstract
- PML regulates a wide range of pathways involved in tumorigenesis, such as apoptosis, which is also one of the main mechanisms through which oxaliplatin and fluoropyrimidine exert their antineoplastic activity. The present study aims to investigate PML expression as a predictive factor of oxaliplatin/fluoropyrimidine therapy efficacy. Seventy-four metastatic colorectal cancer patients who received oxaliplatin/floropyrimidine-based first line therapy have been included in this retrospective study. PML expression was assessed by immunohistochemistry. PML down-regulation was detected in 39 (52.7%) patients (14 complete and 25 partial PML loss). RR was significantly lower (25.6%) in patients with PML down-regulation than in patients with preserved PML expression (60%) (P = 0.006). Median TTP was 5.5 months when PML was down-regulated versus 11.9 months in case of preserved PML expression (P < 0.0001). A statistical significant difference was also detected in OS (15.6 and 24.5 months, respectively, P = 0.003). The impact of PML down-regulation on TTP and OS was statistically significant also in a multivariate model. This study represents the first evidence of a possible correlation between PML protein expression and outcome of metastatic colorectal cancer patients treated with oxaliplatin/fluoropyrimidine-based first line therapy.<br /> (Copyright © 2011 Wiley Periodicals, Inc.)
- Subjects :
- Adult
Aged
Antimetabolites, Antineoplastic therapeutic use
Capecitabine
Colorectal Neoplasms secondary
Deoxycytidine analogs & derivatives
Deoxycytidine therapeutic use
Drug Resistance, Neoplasm physiology
Female
Fluorouracil analogs & derivatives
Humans
Leucovorin therapeutic use
Male
Middle Aged
Organoplatinum Compounds therapeutic use
Oxaliplatin
Oxaloacetates
Predictive Value of Tests
Promyelocytic Leukemia Protein
Retrospective Studies
Survival Rate
Antineoplastic Agents therapeutic use
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Colorectal Neoplasms drug therapy
Colorectal Neoplasms metabolism
Fluorouracil therapeutic use
Nuclear Proteins metabolism
Transcription Factors metabolism
Tumor Suppressor Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1097-4652
- Volume :
- 227
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of cellular physiology
- Publication Type :
- Academic Journal
- Accession number :
- 21503888
- Full Text :
- https://doi.org/10.1002/jcp.22801