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Pulmonary hypertension, nitric oxide and nitric oxide-releasing compounds.
- Source :
-
Expert review of respiratory medicine [Expert Rev Respir Med] 2011 Apr; Vol. 5 (2), pp. 163-71. - Publication Year :
- 2011
-
Abstract
- Nitric oxide (NO) is an important molecule in the mammalian cardiovascular system and the elucidation of its biological role has led to the awarding of a Nobel prize in medicine. There have been many significant discoveries in NO biology over the past two decades and translation of these developments from bench to bedside has allowed an explosion of therapies for pulmonary hypertension. This article provides an overview of the NO pathway in the pulmonary circulation in maintenance of normal vascular tone as well as its dysregulation in pulmonary hypertension, and a discussion of therapies based on inhaled NO or manipulation of its downstream signaling pathways. Several therapies such as phosphodiesterase inhibitors are already in use, and various experimental therapies are also discussed.
- Subjects :
- Administration, Inhalation
Animals
Antihypertensive Agents administration & dosage
Blood Pressure drug effects
Endothelium, Vascular metabolism
Endothelium, Vascular physiopathology
Humans
Hypertension, Pulmonary metabolism
Hypertension, Pulmonary physiopathology
Nitric Oxide administration & dosage
Nitric Oxide metabolism
Signal Transduction drug effects
Treatment Outcome
Vasodilation drug effects
Vasodilator Agents administration & dosage
Antihypertensive Agents therapeutic use
Endothelium, Vascular drug effects
Hypertension, Pulmonary drug therapy
Nitric Oxide therapeutic use
Nitric Oxide Donors therapeutic use
Vasodilator Agents therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1747-6356
- Volume :
- 5
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Expert review of respiratory medicine
- Publication Type :
- Academic Journal
- Accession number :
- 21510727
- Full Text :
- https://doi.org/10.1586/ers.11.5