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Structure-activity relationship studies of CNS agents. Part II. De novo analysis of the monoamine uptake inhibition data of 1-alkylamino-4-aryltetralins.

Authors :
Mokrosz JL
Source :
Polish journal of pharmacology and pharmacy [Pol J Pharmacol Pharm] 1990 Sep-Oct; Vol. 42 (5), pp. 501-7.
Publication Year :
1990

Abstract

A quantitative structure-activity relationship (QSAR) was analyzed for monoamine uptake inhibition of cis- and trans-1-alkylamino-4-aryltetralins using the Free-Wilson method. The calculated individual substituent contributions were found to be strongly correlated with the uptake inhibition activity of dopamine, 5-hydroxytryptamine and norepinephrine in the corpus striatum and hypothalamus of rats, respectively. The effect of the substituents and stereochemical factors on the monoamine uptake inhibition of the analyzed series of tetralins was discussed.

Details

Language :
English
ISSN :
0301-0244
Volume :
42
Issue :
5
Database :
MEDLINE
Journal :
Polish journal of pharmacology and pharmacy
Publication Type :
Academic Journal
Accession number :
2151534