Back to Search
Start Over
Structure-activity relationship studies of CNS agents. Part II. De novo analysis of the monoamine uptake inhibition data of 1-alkylamino-4-aryltetralins.
- Source :
-
Polish journal of pharmacology and pharmacy [Pol J Pharmacol Pharm] 1990 Sep-Oct; Vol. 42 (5), pp. 501-7. - Publication Year :
- 1990
-
Abstract
- A quantitative structure-activity relationship (QSAR) was analyzed for monoamine uptake inhibition of cis- and trans-1-alkylamino-4-aryltetralins using the Free-Wilson method. The calculated individual substituent contributions were found to be strongly correlated with the uptake inhibition activity of dopamine, 5-hydroxytryptamine and norepinephrine in the corpus striatum and hypothalamus of rats, respectively. The effect of the substituents and stereochemical factors on the monoamine uptake inhibition of the analyzed series of tetralins was discussed.
Details
- Language :
- English
- ISSN :
- 0301-0244
- Volume :
- 42
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Polish journal of pharmacology and pharmacy
- Publication Type :
- Academic Journal
- Accession number :
- 2151534