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The association between malignancy and end-stage renal disease in Taiwan.
- Source :
-
Japanese journal of clinical oncology [Jpn J Clin Oncol] 2011 Jun; Vol. 41 (6), pp. 752-7. Date of Electronic Publication: 2011 Apr 22. - Publication Year :
- 2011
-
Abstract
- Objective: Patients with end-stage renal disease are suggestive to have a higher risk for the development of some kinds of cancer. The aim of this study is to evaluate the possible association between malignancy and end-stage renal disease in Taiwan.<br />Methods: We used the data of the National Health Insurance system of Taiwan to assess this issue. The end-stage renal disease cohort contained 21 817 patients, and each patient was randomly frequency-matched with two people from the general population without end-stage renal disease based on their age and sex. The Cox proportional hazard regression analysis was conducted to estimate the effects of end-stage renal disease on the cancer risk.<br />Results: In patients with end-stage renal disease, the risk of developing overall cancer was significantly higher than the normal healthy subjects (adjusted hazard ratio = 1.64, 95% confidence interval = 1.54-1.74). This was also true when we analyzed males and females separately. For individual cancer, the risks for developing urinary tract cancers, liver cancer and breast cancer among patients with end-stage renal disease were significantly higher. On the contrary, lung, prostate and esophageal cancer risks were significantly lower when compared with the normal healthy subjects.<br />Conclusions: Our study found Taiwanese patients with end-stage renal disease to have a higher risk to develop urinary tract, liver and breast cancer. We unexpectedly discovered these patients to have a lower risk to get lung, prostate and esophageal cancer.
- Subjects :
- Adult
Aged
Breast Neoplasms epidemiology
Carcinoma, Renal Cell epidemiology
Cohort Studies
Esophageal Neoplasms epidemiology
Female
Humans
Kidney Neoplasms epidemiology
Liver Neoplasms epidemiology
Lung Neoplasms epidemiology
Male
Middle Aged
Odds Ratio
Proportional Hazards Models
Prostatic Neoplasms epidemiology
Risk Assessment
Risk Factors
Taiwan epidemiology
Urologic Neoplasms epidemiology
Kidney Failure, Chronic complications
Kidney Failure, Chronic epidemiology
Neoplasms epidemiology
Neoplasms etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1465-3621
- Volume :
- 41
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Japanese journal of clinical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 21515610
- Full Text :
- https://doi.org/10.1093/jjco/hyr051