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Association between moderately oxidized low-density lipoprotein and high-density lipoprotein particle subclass distribution in hemodialyzed and post-renal transplant patients.
- Source :
-
Journal of Zhejiang University. Science. B [J Zhejiang Univ Sci B] 2011 May; Vol. 12 (5), pp. 365-71. - Publication Year :
- 2011
-
Abstract
- Disturbances in the metabolism of lipoprotein profiles and oxidative stress in hemodialyzed (HD) and post-renal transplant (Tx) patients are proatherogenic, but elevated concentrations of plasma high-density lipoprotein (HDL) reduce the risk of cardiovascular disease. We investigated the concentrations of lipid, lipoprotein, HDL particle, oxidized low-density lipoprotein (ox-LDL) and anti-ox-LDL, and paraoxonase-1 (PON-1) activity in HD (n=33) and Tx (n=71) patients who were non-smokers without active inflammatory disease, liver disease, diabetes, or malignancy. HD patients had moderate hypertriglyceridemia, normocholesterolemia, low HDL-C, apolipoprotein A-I (apoA-I) and HDL particle concentrations as well as PON-1 activity, and increased ox-LDL and anti-ox-LDL levels. Tx patients had hypertriglyceridemia, hypercholesterolemia, moderately decreased HDL-C and HDL particle concentrations and PON-1 activity, and moderately increased ox-LDL and anti-ox-LDL levels as compared to the reference, but ox-LDL and anti-ox-LDL levels and PON-1 activity were more disturbed in HD patients. However, in both patient groups, lipid and lipoprotein ratios (total cholesterol (TC)/HDL-C, LDL-C/HDL-C, triglyceride (TG)/HDL-C, HDL-C/non-HDL-C, apoA-I/apoB, HDL-C/apoA-I, TG/HDL) were atherogenic. The Spearman's rank coefficient test showed that the concentration of ox-LDL correlated positively with HDL particle level (R=0.363, P=0.004), and negatively with TC (R=-0.306, P=0.012), LDL-C (R=-0.283, P=0.020), and non-HDL-C (R=-0.263, P=0.030) levels in Tx patients. Multiple stepwise forward regression analysis in Tx patients demonstrated that ox-LDL concentration, as an independent variable, was associated significantly positively with HDL particle level. The results indicated that ox-LDL and decreased PON-1 activity in Tx patients may give rise to more mildly-oxidized HDLs, which are less stable, easily undergo metabolic remodeling, generate a greater number of smaller pre-β-HDL particles, and thus accelerate reverse cholesterol transport, which may be beneficial for Tx patients. Further studies are necessary to confirm this.
- Subjects :
- Adult
Aged
Antibodies blood
Aryldialkylphosphatase blood
Atherosclerosis blood
Atherosclerosis etiology
Case-Control Studies
Female
Humans
Kidney Failure, Chronic blood
Kidney Failure, Chronic complications
Kidney Failure, Chronic immunology
Kidney Failure, Chronic therapy
Leptin blood
Lipoproteins, LDL chemistry
Lipoproteins, LDL immunology
Male
Middle Aged
Oxidation-Reduction
Oxidative Stress
Risk Factors
Young Adult
Kidney Transplantation
Lipoproteins, HDL blood
Lipoproteins, HDL classification
Lipoproteins, LDL blood
Lipoproteins, LDL classification
Renal Dialysis
Subjects
Details
- Language :
- English
- ISSN :
- 1862-1783
- Volume :
- 12
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of Zhejiang University. Science. B
- Publication Type :
- Academic Journal
- Accession number :
- 21528490
- Full Text :
- https://doi.org/10.1631/jzus.B1000348