Involvement of protein kinase C in the galanin-induced antinociception in the brain of rats.

Authors :: Shi J
Fu LB
Yu LC
Source :: Neuroscience letters [Neurosci Lett] 2011 Jun 15; Vol. 497 (1), pp. 60-3. Date of Electronic Publication: 2011 Apr 20.
Publication Year :: 2011
Abstract: Previous study in our laboratory demonstrates that microinjection of galanin into the arcuate nucleus of hypothalamus produced antinociceptive effects in rats. In the present study we investigated the involvement of protein kinase C (PKC) and PKC signaling pathways in the galanin-induced antinociception in the brain of rats. Intracerebroventricular injection of galanin produced antinociceptive effects in rats tested by hot-plate and Randall Selitto test. Interestingly, the galanin-induced antinociception was significantly attenuated by intracerebroventricular injection of the PKC inhibitor chelerythrine, indicating an involvement of PKC in the galanin-induced antinociception in rats. Taken together, the results demonstrate that galanin induces antinociceptive effects in the rat brain, and PKC is involved in the galanin-induced antinociception in the brain of rats.<br /> (Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.)

Subjects :: Animals
Brain drug effects
Enzyme Inhibitors pharmacology
Galanin administration & dosage
Injections, Intraventricular
Male
Rats
Rats, Sprague-Dawley
Signal Transduction drug effects
Brain metabolism
Galanin metabolism
Pain physiopathology
Protein Kinase C metabolism
Signal Transduction physiology

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