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Immunologic monitoring of cellular responses by dendritic/tumor cell fusion vaccines.
- Source :
-
Journal of biomedicine & biotechnology [J Biomed Biotechnol] 2011; Vol. 2011, pp. 910836. Date of Electronic Publication: 2011 Apr 26. - Publication Year :
- 2011
-
Abstract
- Although dendritic cell (DC)- based cancer vaccines induce effective antitumor activities in murine models, only limited therapeutic results have been obtained in clinical trials. As cancer vaccines induce antitumor activities by eliciting or modifying immune responses in patients with cancer, the Response Evaluation Criteria in Solid Tumors (RECIST) and WHO criteria, designed to detect early effects of cytotoxic chemotherapy in solid tumors, may not provide a complete assessment of cancer vaccines. The problem may, in part, be resolved by carrying out immunologic cellular monitoring, which is one prerequisite for rational development of cancer vaccines. In this review, we will discuss immunologic monitoring of cellular responses for the evaluation of cancer vaccines including fusions of DC and whole tumor cell.
Details
- Language :
- English
- ISSN :
- 1110-7251
- Volume :
- 2011
- Database :
- MEDLINE
- Journal :
- Journal of biomedicine & biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 21541197
- Full Text :
- https://doi.org/10.1155/2011/910836