Back to Search
Start Over
Therapeutic effectiveness of botulinum toxin type A based on severity of palmar hyperhidrosis.
- Source :
-
The Journal of dermatology [J Dermatol] 2011 Sep; Vol. 38 (9), pp. 859-63. Date of Electronic Publication: 2011 May 04. - Publication Year :
- 2011
-
Abstract
- A dose of 60 units (U) of botulinum toxin type A (BT-A) has been confirmed to have efficacy for patients with palmoplantar hyperhidrosis. However, the effectiveness of this dose is limited in severe cases defined as sweat production of 2 mg/cm(2) per min or more (measured by the ventilated capsule method) and a Hyperhidrosis Disease Severity Scale (HDSS) grade of 3 or 4. An increased dose of 90 U of BT-A was found to reduce sweating for approximately 7 months. In a comparison of patients with sweat production of more than 2.5 mg/cm(2) per min and an HDSS grade of 4 and patients with sweat production of 2.5 mg/cm(2) per min or less and an HDSS grade of 3, there was no difference in the reduction of sweat production at 5 months, but the duration of the reduced sweating was shorter for the former group. This suggests that there are limits to the efficacy of BT-A for severe forms of the disease with sweat production of more than 2.5 mg/cm(2) per mL.<br /> (© 2011 Japanese Dermatological Association.)
- Subjects :
- Adult
Botulinum Toxins, Type A administration & dosage
Dose-Response Relationship, Drug
Female
Hand
Humans
Hyperhidrosis physiopathology
Injections, Intradermal
Male
Severity of Illness Index
Sweating drug effects
Time Factors
Treatment Outcome
Botulinum Toxins, Type A therapeutic use
Hyperhidrosis drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1346-8138
- Volume :
- 38
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- The Journal of dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 21545498
- Full Text :
- https://doi.org/10.1111/j.1346-8138.2011.01214.x