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Patch testing with hydroxyethyl-p-phenylenediamine sulfate - cross-reactivity with p-phenylenediamine.
- Source :
-
Contact dermatitis [Contact Dermatitis] 2011 Aug; Vol. 65 (2), pp. 96-100. Date of Electronic Publication: 2011 May 06. - Publication Year :
- 2011
-
Abstract
- Background: Adverse reactions to permanent hair dyes are frequent, and primarily result from sensitization to p-phenylenediamine (PPD).<br />Objectives: To investigate the degree of cross-reactivity to a chemically similar dye, hydroxyethyl-p-phenylenediamine sulfate (HPPS), and whether this might be a dyeing alternative for patients who are sensitive to PPD.<br />Method: HPPS was patch tested in two concentrations in a total of 216 patients suspected of having contact dermatitis caused by hair dyes and/or hair cosmetics. A regular use test with a hair dye containing HPPS was suggested to every patient who had had an adverse reaction to a PPD hair dye in the past.<br />Results: Forty of 216 (19.9%) patients reacted to 1% PPD, whereas only 2/216 (0.9%) showed a positive reaction to 1% HPPS. Reactivity to 2% HPPS was only slightly higher (5/216, 2.3%). On the basis of the 43 PPD-positive patients, the reactivity to 2% HPPS amounted to 12%; the corresponding figure for toluene-2,5-diamine was 15% (5/33). In a use test on two PPD-positive patients with a hair dye containing HPPS, no adverse reaction was seen, even after several years of regular dyeing. CONCLUSIONS. HPPS may be an alternative hair dye for individuals not tolerating PPD-containing dyes. However, cross-reactivity with PPD and other aromatic amines may occur. HPPS is also a known sensitizer, and the risk of de novo sensitization can only be assessed by a controlled study on a large panel and under regular use conditions.<br /> (© 2011 John Wiley & Sons A/S.)
- Subjects :
- Adult
Coloring Agents adverse effects
Coloring Agents chemistry
Dermatitis, Allergic Contact epidemiology
Dermatitis, Allergic Contact etiology
Dose-Response Relationship, Drug
Drug Interactions
Female
Germany epidemiology
Hair Dyes adverse effects
Humans
Male
Middle Aged
Phenylenediamines adverse effects
Prevalence
Sensitivity and Specificity
Dermatitis, Allergic Contact diagnosis
Patch Tests
Phenylenediamines chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1600-0536
- Volume :
- 65
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Contact dermatitis
- Publication Type :
- Academic Journal
- Accession number :
- 21545602
- Full Text :
- https://doi.org/10.1111/j.1600-0536.2011.01916.x