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Methylene blue in the treatment of refractory shock from an amlodipine overdose.
- Source :
-
Annals of emergency medicine [Ann Emerg Med] 2011 Dec; Vol. 58 (6), pp. 565-7. Date of Electronic Publication: 2011 May 05. - Publication Year :
- 2011
-
Abstract
- Amlodipine is a potent vasodilator with a long half-life and delayed onset of action that is particularly concerning after an overdose. Vasodilation occurs through stimulation of nitric oxide release with increased cyclic guanosine monophosphate (cGMP) production. Methylene blue inhibits guanylate cyclase. This enzyme is responsible for the production of cGMP. Methylene blue also has the ability to scavenge nitric oxide, as well as inhibit nitric oxide synthase. We report the use of methylene blue for refractory shock in a patient with amlodipine toxicity.<br /> (Copyright © 2011 American College of Emergency Physicians. Published by Mosby, Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1097-6760
- Volume :
- 58
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Annals of emergency medicine
- Publication Type :
- Academic Journal
- Accession number :
- 21546119
- Full Text :
- https://doi.org/10.1016/j.annemergmed.2011.02.025