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[Molecular mechanisms involved in the treatment of inflammatory bowel disease by Pulsatilla decoction].
- Source :
-
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology [Zhongguo Ying Yong Sheng Li Xue Za Zhi] 2011 Feb; Vol. 27 (1), pp. 106-9. - Publication Year :
- 2011
-
Abstract
- Objective: To investigate molecular mechanisms underlying in the treatment of inflammatory bowel disease by Pulsatilla decoction.<br />Methods: Wistar male rats were randomly divided into control group, model group, model + positive control group (mesalazine), traditional Chinese medicine treatment group, in addition, the Chinese medical treatment group was divided into middle and high dose group ( n = 8). Intragastric administration was used in the positive control group and traditional Chinese medicine treatment group. The expression of Smad7 and p-Smad3 in the colons were detected by immunohistochemistry and Western blot.<br />Results: Compared with the model group, positive medicine and traditional Chinese medicine group, especially high-dose group, could effectively inhibit the expression of Smad7, while enhancing the p-Smad3 expression.<br />Conclusion: The activation of TGF-beta1/Smad3 signaling pathway may be the molecular mechanism underlying in the anti-inflammatory effect of inflammatory bowel disease by Pulsatilla decoction.
Details
- Language :
- Chinese
- ISSN :
- 1000-6834
- Volume :
- 27
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology
- Publication Type :
- Academic Journal
- Accession number :
- 21560356