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[Diagnostic value of alginate test in gastroesophageal reflux disease].
- Source :
-
Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology [Eksp Klin Gastroenterol] 2010 (12), pp. 102-7. - Publication Year :
- 2010
-
Abstract
- Aim of Study: To evaluate the diagnostic accuracy of single dose of gaviscon (the alginates test) in detecting gastroesophageal reflux disease (GERD) in patients with heartburn symptoms.<br />Material and Methods: 123 patients (male 46, female 77, age 43.6 +/- 15.5 years) with symptoms suggestive of GERD were investigated. Symptom response to the alginates test compared in GERD positive and GERD negative patients according traditional diagnostic criteria of GERD (upper endoscopy, 24-hr pH-monitoring, esophageal manometry, response to treatment with PPIs).<br />Results: Of 91 (78.9%) patients with positive alginates test, 87 were classified as GERD positive and 4 as GERD negative. Of 32 (26%) patients with negative alginates test, 29 were GERD negative and 3 GERD positive. The results providing a sensitivity of alginates test of 96.7% and a specificity of 87.7%.<br />Conclusions: The alginates test is sensitive and specific for diagnosing GERD in patients with typical GERD symptoms.
- Subjects :
- Adult
Biocompatible Materials administration & dosage
Drug Combinations
Endoscopy, Digestive System methods
Female
Gastroesophageal Reflux pathology
Gastroesophageal Reflux physiopathology
Glucuronic Acid administration & dosage
Hexuronic Acids administration & dosage
Humans
Hydrogen-Ion Concentration
Male
Middle Aged
Monitoring, Physiologic methods
Alginates administration & dosage
Aluminum Hydroxide administration & dosage
Antacids administration & dosage
Gastroesophageal Reflux diagnosis
Silicic Acid administration & dosage
Sodium Bicarbonate administration & dosage
Subjects
Details
- Language :
- Russian
- ISSN :
- 1682-8658
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 21560632