Blocking by anti-idiotypic antibodies of monoclonal antibody mediated protection in mice against encephalomyocarditis virus induced diabetes and lethal disease.

Authors :: Vlaspolder F
Oosterlaken TA
Harmsen M
van Dijk PW
Kievit H
Kraaijeveld CA
Snippe H
Source :: Archives of virology [Arch Virol] 1990; Vol. 110 (3-4), pp. 277-85.
Publication Year :: 1990
Abstract: Monoclonal antibodies (MA) UM 21.1 and UM 21.2 protect mice against encephalomyocarditis virus (D-variant) induced diabetes and lethal disease. MA-mediated protection in vivo as well as neutralization in vitro could be specifically blocked by anti-idiotypic antibodies.

Subjects :: Animals
Antibodies, Anti-Idiotypic administration & dosage
Antibodies, Monoclonal immunology
Diabetes Mellitus, Experimental etiology
Diabetes Mellitus, Experimental immunology
Encephalomyocarditis virus immunology
Enterovirus Infections immunology
Immunity
Immunoenzyme Techniques
Male
Mice
Mice, Inbred BALB C
Mice, Inbred DBA
Viral Vaccines immunology
Antibodies, Anti-Idiotypic immunology
Antibodies, Monoclonal administration & dosage
Diabetes Mellitus, Experimental prevention & control
Enterovirus Infections prevention & control
Viral Vaccines administration & dosage

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