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[Nimotuzumab in combination with chemotherapy for patients with malignant gliomas].
- Source :
-
Zhonghua zhong liu za zhi [Chinese journal of oncology] [Zhonghua Zhong Liu Za Zhi] 2011 Mar; Vol. 33 (3), pp. 232-5. - Publication Year :
- 2011
-
Abstract
- Objective: Nimotuzumab is a humanized monoclonal antibody targeted against epidermal growth factor receptor (EGFR). Recent clinical studies show that patients with malignant gliomas could benefit from nimotuzumab treatment. The aim of the present study was to evaluate the efficacy and side effects of nimotuzumab in combination with chemotherapy for patients with malignant gliomas.<br />Methods: The patients received 200 mg of nimotuzumab infusion intravenously over 60 minutes once weekly for the first eight weeks and then once every two weeks until unacceptable toxicity or tumor progression occurred. Individualized chemotherapy was administered based on O(6)-methylguanine-DNA methyltransferase (MGMT) expression and previous chemotherapy responses in combined with nimotuzumab.<br />Results: Fourteen patients received a total of 122 times of nimotuzumab ranging from 2 to 20 (median 7.5 times). Combined chemotherapy regimens included: continuous 21-day temozolomide (10 cases), standard 5-day temozolomide (2 cases), teniposide plus cisplatin (1 case), and teniposide plus nimustine (1 case). Partial response (PR) and stable disease (SD) were found in 3 patients (21.4%)and 6 patients (42.9%), respectively. Disease control rate (PR + SD) was 64.3%. The median progression-free survival (PFS) was 4 months (95%CI: 0.7 - 7.3) and PFS at 6 months was 30.6%. The most common toxicities include grade I-II neutropenia (2 cases), thrombocytopenia (2 cases), lymphopenia (1 case), nausea and vomitting (3 case) and asymptomatic transaminase increase (1 case). One patient developed grade IV neutropenia and thrombocytopenia. One patient developed nimotuzumab-related acneiform rash.<br />Conclusions: Nimotuzumab in combination with chemotherapy has moderate activity in patients with malignant gliomas and the toxicities are well tolerable, therefore, worth further investigation.
- Subjects :
- Adolescent
Adult
Antibodies, Monoclonal, Humanized administration & dosage
Antibodies, Monoclonal, Humanized adverse effects
Antineoplastic Agents, Alkylating adverse effects
Antineoplastic Agents, Alkylating therapeutic use
Antineoplastic Combined Chemotherapy Protocols adverse effects
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Astrocytoma drug therapy
Child
Cisplatin administration & dosage
Cisplatin adverse effects
Dacarbazine adverse effects
Dacarbazine analogs & derivatives
Dacarbazine therapeutic use
Disease-Free Survival
Female
Humans
Infusions, Intravenous
Male
Nausea chemically induced
Neutropenia chemically induced
Nimustine administration & dosage
Nimustine adverse effects
Temozolomide
Teniposide administration & dosage
Teniposide adverse effects
Thrombocytopenia chemically induced
Young Adult
Antibodies, Monoclonal, Humanized therapeutic use
Glioblastoma drug therapy
Glioma drug therapy
Subjects
Details
- Language :
- Chinese
- ISSN :
- 0253-3766
- Volume :
- 33
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Zhonghua zhong liu za zhi [Chinese journal of oncology]
- Publication Type :
- Academic Journal
- Accession number :
- 21575527