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Biologically predisposed learning and selective associations in amygdalar neurons.
- Source :
-
Learning & memory (Cold Spring Harbor, N.Y.) [Learn Mem] 2011 May 16; Vol. 18 (6), pp. 371-4. Date of Electronic Publication: 2011 May 16 (Print Publication: 2011). - Publication Year :
- 2011
-
Abstract
- Modern views on learning and memory accept the notion of biological constraints-that the formation of association is not uniform across all stimuli. Yet cellular evidence of the encoding of selective associations is lacking. Here, conditioned stimuli (CSs) and unconditioned stimuli (USs) commonly employed in two basic associative learning paradigms, fear conditioning and taste aversion conditioning, were delivered in a manner compatible with a functional cellular imaging technique (Arc cellular compartmental analysis of temporal gene transcription by fluorescence in situ hybridization [catFISH]) to identify biological constraints on CS-US convergence at the level of neurons in basolateral amygdala (BLA). Results indicate coincident Arc mRNA activation within BLA neurons after CS-US combinations that yield rapid, efficient learning, but not after CS-US combinations that do not.
- Subjects :
- Analysis of Variance
Animals
Apoptosis Regulatory Proteins genetics
Apoptosis Regulatory Proteins metabolism
Avoidance Learning physiology
Diterpenes administration & dosage
Electroshock adverse effects
Fear
Furans administration & dosage
Lithium Chloride administration & dosage
Male
Muscle Proteins genetics
Muscle Proteins metabolism
Random Allocation
Rats
Rats, Sprague-Dawley
Taste physiology
Amygdala cytology
Association Learning physiology
Conditioning, Classical physiology
Neurons physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1549-5485
- Volume :
- 18
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Learning & memory (Cold Spring Harbor, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 21576517
- Full Text :
- https://doi.org/10.1101/lm.2053711