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[Pleomorphism of the myelin-like bodies in the hepatocytes of patients with Dubin-Johnson syndrome complicated with chronic hepatitis B].
- Source :
-
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology [Zhonghua Gan Zang Bing Za Zhi] 2011 Mar; Vol. 19 (3), pp. 210-3. - Publication Year :
- 2011
-
Abstract
- Objective: To explore characteristics of the myelin-like bodies in the hepatocytes of patients with Dubin-Johnson syndrome (DJS) complicated with chronic hepatitis B (CHB).<br />Methods: 11 cases of DJS complicated with CHB and 5 cases DJS without CHB were studied clinicopathologically. The hepatocyte ultrastructure was observed with transmission electron microscope and taken photos. The data were compared and analyzed using Fisher's Exact Test.<br />Results: Deposition of myelin-like bodies can be observed in the hepatocytes of DJS patients with CHB but can not in DJS patients without CHB. The morphology of pigment varys. The electron density and volume of pigment in DJS patients with CHB can be classified into five types: brights (2/11,18.2%), reticulation (1/11, 9.1%), punctiform (6/11, 54.5%), abnormity (1/11, 9.1%) and primary type (1/11, 9.1%). The myelin-like bodies in the hepatocytes of patients with DJS are high density and round with membrance (we named it as primary type) (5/5, 100%).<br />Conclusions: The myelin-like bodies in the hepatocytes of DJS patients with CHB possess special pleomorphism and may have important diagnostic value.
- Subjects :
- Adolescent
Adult
Female
Hepatitis B, Chronic complications
Hepatocytes chemistry
Humans
Jaundice, Chronic Idiopathic complications
Male
Young Adult
Hepatitis B, Chronic pathology
Hepatocytes pathology
Hepatocytes ultrastructure
Jaundice, Chronic Idiopathic pathology
Myelin Sheath ultrastructure
Subjects
Details
- Language :
- Chinese
- ISSN :
- 1007-3418
- Volume :
- 19
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology
- Publication Type :
- Academic Journal
- Accession number :
- 21586241
- Full Text :
- https://doi.org/10.3760/cma.j.issn.1007-3418.2011.03.014