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Effects of allitridin on acute and chronic mouse cytomegalovirus infection.
- Source :
-
Archives of virology [Arch Virol] 2011 Oct; Vol. 156 (10), pp. 1841-6. Date of Electronic Publication: 2011 May 22. - Publication Year :
- 2011
-
Abstract
- This study investigated the effects of allitridin on acute and chronic mouse cytomegalovirus (MCMV) infections in vivo. The results demonstrated that allitridin reduced the titers of MCMV in salivary glands, and reductions in viral loads were confirmed by determining viral DNA and RNA levels in susceptible organs during the acute infection phase. Although allitridin did not eliminate MCMV, treatment reduced viral levels and facilitated healing of pathologic lesions in organs, particularly during the chronic infection phase. The results presented in this report suggest that allitridin could act as an effective agent against MCMV infections in vivo.
- Subjects :
- Acute Disease therapy
Animals
Chronic Disease therapy
Cytomegalovirus drug effects
Cytomegalovirus physiology
Cytomegalovirus Infections drug therapy
Disease Models, Animal
Female
Herpesviridae Infections drug therapy
Humans
Mice
Mice, Inbred BALB C
Muromegalovirus physiology
Salivary Glands virology
Viral Load drug effects
Allyl Compounds pharmacology
Antiviral Agents pharmacology
Cytomegalovirus Infections virology
Herpesviridae Infections virology
Muromegalovirus drug effects
Sulfides pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1432-8798
- Volume :
- 156
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Archives of virology
- Publication Type :
- Academic Journal
- Accession number :
- 21604182
- Full Text :
- https://doi.org/10.1007/s00705-011-1025-9