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Effects of allitridin on acute and chronic mouse cytomegalovirus infection.

Authors :
Liu XL
Wang H
Li YN
Ge HX
Shu SN
Fang F
Source :
Archives of virology [Arch Virol] 2011 Oct; Vol. 156 (10), pp. 1841-6. Date of Electronic Publication: 2011 May 22.
Publication Year :
2011

Abstract

This study investigated the effects of allitridin on acute and chronic mouse cytomegalovirus (MCMV) infections in vivo. The results demonstrated that allitridin reduced the titers of MCMV in salivary glands, and reductions in viral loads were confirmed by determining viral DNA and RNA levels in susceptible organs during the acute infection phase. Although allitridin did not eliminate MCMV, treatment reduced viral levels and facilitated healing of pathologic lesions in organs, particularly during the chronic infection phase. The results presented in this report suggest that allitridin could act as an effective agent against MCMV infections in vivo.

Details

Language :
English
ISSN :
1432-8798
Volume :
156
Issue :
10
Database :
MEDLINE
Journal :
Archives of virology
Publication Type :
Academic Journal
Accession number :
21604182
Full Text :
https://doi.org/10.1007/s00705-011-1025-9