Back to Search
Start Over
The relation of HLA genotype to hepatitis C viral load and markers of liver fibrosis in HIV-infected and HIV-uninfected women.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2011 Jun 15; Vol. 203 (12), pp. 1807-14. - Publication Year :
- 2011
-
Abstract
- Background: Human leukocyte antigen (HLA) class I and II genotype is associated with clearance of hepatitis C virus (HCV) infection, but little is known regarding its relation with HCV viral load or risk of liver disease in patients with persistent HCV infection.<br />Methods: High-resolution HLA class I and II genotyping was conducted in a prospective cohort of 519 human immunodeficiency virus (HIV)-seropositive and 100 HIV-seronegative women with persistent HCV infection. The end points were baseline HCV viral load and 2 noninvasive indexes of liver disease, fibrosis-4 (FIB-4), and the aspartate aminotransferase to platelet ratio index (APRI), measured at baseline and prospectively.<br />Results: DQB1*0301 was associated with low baseline HCV load (β = -.4; 95% confidence interval [CI], -.6 to -.3; P < .00001), as well as with low odds of FIB-4-defined (odds ratio [OR], .5; 95% CI, .2-.9; P = .02) and APRI-defined liver fibrosis (OR, .5; 95% CI, .3-1.0; P = .06) at baseline and/or during follow-up. Most additional associations with HCV viral load also involved HLA class II alleles. Additional associations with FIB-4 and APRI primarily involved class I alleles, for example, the relation of B*1503 with APRI-defined fibrosis had an OR of 2.0 (95% CI, 1.0-3.7; P = .04).<br />Conclusions: HLA genotype may influence HCV viral load and risk of liver disease, including DQB1*0301, which was associated with HCV clearance in prior studies.
- Subjects :
- Adult
Alanine Transaminase blood
Alleles
Aspartate Aminotransferases blood
Cohort Studies
Female
Genotype
HLA-DQ Antigens genetics
Hepatitis C, Chronic complications
Humans
Liver Cirrhosis blood
Liver Cirrhosis virology
Logistic Models
Platelet Count
Prospective Studies
United States
HIV Infections complications
HLA Antigens genetics
Hepacivirus pathogenicity
Hepatitis C, Chronic virology
Liver Cirrhosis genetics
Viral Load genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1537-6613
- Volume :
- 203
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 21606539
- Full Text :
- https://doi.org/10.1093/infdis/jir192