Xenotransplantation of cryopreserved ovarian tissue from patients with ovarian tumors into SCID mice--no evidence of malignant cell contamination.

Authors :: Lotz L
Montag M
van der Ven H
von Wolff M
Mueller A
Hoffmann I
Wachter D
Beckmann MW
Dittrich R
Source :: Fertility and sterility [Fertil Steril] 2011 Jun 30; Vol. 95 (8), pp. 2612-4.e1. Date of Electronic Publication: 2011 May 31.
Publication Year :: 2011
Abstract: This study examined the possible presence of malignant cells in ovarian cortex from patients with ovarian tumors after xenografting of the ovarian tissue into severe combined immunodeficiency mice. None of the mice presented symptoms of reintroduced malignancy nor did microscopic and immunohistochemical evaluation of the grafts raise any suspicion of residual malignant disease.<br /> (Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.)

Full Text Access

Tools