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Charting the peptide crossreactome between HIV-1 and the human proteome.
- Source :
-
Frontiers in bioscience (Elite edition) [Front Biosci (Elite Ed)] 2011 Jun 01; Vol. 3 (4), pp. 1385-400. Date of Electronic Publication: 2011 Jun 01. - Publication Year :
- 2011
-
Abstract
- This paper defines potential peptide cross-reactivity between HIV-1 and the human host. Specifically, the amino acid primary sequence of HIV-1, isolate CDC-451, was analyzed for potential immunopathological relationships with the human proteome. The results revealed that: 1) HIV-1 shares 50 heptapeptides and three octapeptides with the human proteome; 2) 34 of the 50 shared heptapeptides are experimentally validated epitopes targeted by immune responses following HIV-1 infection; 3) the viral heptapeptide epitopes are present in human proteins that, when altered, are associated with disease characteristics of acquired immunodeficiency syndrome (AIDS) such as CD4+ cell loss, encephalopathy, schizophrenia, myopathy, cardiovascular disorders, hypertension, corneal diseases, diarrhea, lymphoma, and bladder cancer; 4) at the pentapeptide level, the viral-versus-human overlap is extensive (14,227 matches), with the viral pentapeptides disseminated throughout 10,312 human proteins. The findings are discussed in relationship to HIV-1 escape from immune surveillance, adjuvant-induced HIV-1 immunogenicity, autoimmune cross-reactions following human hyperimmune responses against HIV-1, and AIDS.
- Subjects :
- Cross Reactions
Humans
HIV-1 metabolism
Peptides metabolism
Proteome
Subjects
Details
- Language :
- English
- ISSN :
- 1945-0508
- Volume :
- 3
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Frontiers in bioscience (Elite edition)
- Publication Type :
- Academic Journal
- Accession number :
- 21622144
- Full Text :
- https://doi.org/10.2741/e341