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Effect of thymectomy on cellular immune function.
- Source :
-
Frontiers in bioscience (Landmark edition) [Front Biosci (Landmark Ed)] 2011 Jun 01; Vol. 16 (8), pp. 3036-42. Date of Electronic Publication: 2011 Jun 01. - Publication Year :
- 2011
-
Abstract
- The present study was conducted to evaluate the effect of thymectomy during open heart surgery on immunological function of T lymphocytes in the treatment of children with congenital heart disease (CHD). No significant difference was found in the sjTREC level between pre-thymectomy and post- thymectomy in the non-thymectomy group and the small partial resection group (P>0.05) However, the sjTREC level decreased from the pre-surgical level at 1 month (P<0.01) and 12 months (P<0.01) in the sub-total resection group. No differences were found in proportions of CD3, CD4 and CD8 lymphocytes, proliferative ability of lymphocytes and expression of IL-2, IL-4 and IFN-γ after surgery between controls and three groups of patients (P>0.05). In the sub-total resection group, respiratory infection frequency (4.7±1.7 times) did not differ significantly from control group one year after surgery (P>0.05); however, mean days of anti-infection were significantly increased (P less than 0.01). In conclusion, sub-total thymectomy leads to a decrease in the sjTREC level in CHD children, whereas the function of peripheral mature T lymphocytes is normal.
- Subjects :
- Cardiac Surgical Procedures adverse effects
Cardiac Surgical Procedures methods
Case-Control Studies
Cell Differentiation
Child, Preschool
Cytokines blood
Female
Gene Expression
Gene Rearrangement, T-Lymphocyte
Heart Defects, Congenital immunology
Heart Defects, Congenital surgery
Humans
Infant
Male
Respiratory Tract Infections etiology
Respiratory Tract Infections immunology
T-Lymphocyte Subsets cytology
T-Lymphocyte Subsets immunology
Immunity, Cellular genetics
Thymectomy adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 2768-6698
- Volume :
- 16
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Frontiers in bioscience (Landmark edition)
- Publication Type :
- Academic Journal
- Accession number :
- 21622219
- Full Text :
- https://doi.org/10.2741/3896