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Repeated sauna therapy attenuates ventricular remodeling after myocardial infarction in rats by increasing coronary vascularity of noninfarcted myocardium.
- Source :
-
American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2011 Aug; Vol. 301 (2), pp. H548-54. Date of Electronic Publication: 2011 May 27. - Publication Year :
- 2011
-
Abstract
- Repeated sauna therapy (ST) increases endothelial nitric oxide synthase (eNOS) activity and improves cardiac function in heart failure as well as peripheral blood flow in ischemic limbs. The present study investigates whether ST can increase coronary vascularity and thus attenuate cardiac remodeling after myocardial infarction (MI). We induced MI by ligating the left coronary artery of Wistar rats. The rats were placed in a far-infrared dry sauna at 41°C for 15 min and then at 34°C for 20 min once daily for 4 wk. Cardiac hemodynamic, histopathological, and gene analyses were performed. Despite the similar sizes of MI between the ST and non-ST groups (51.4 ± 0.3 vs. 51.1 ± 0.2%), ST reduced left ventricular (LV) end-diastolic (9.7 ± 0.4 vs. 10.7 ± 0.5 mm, P < 0.01) and end-systolic (8.6 ± 0.5 vs. 9.6 ± 0.6 mm, P < 0.01) dimensions and attenuated MI-induced increases in LV end-diastolic pressure. Cross-sectional areas of cardiomyocytes were smaller in ST rats and associated with a significant reduction in myocardial atrial natriuretic peptide mRNA levels. Vascular density was reduced in the noninfarcted myocardium of non-ST rats, and the density of cells positive for CD31 and for α-smooth muscle actin was decreased. These decreases were attenuated in ST rats compared with non-ST rats and associated with increases in myocardial eNOS and vascular endothelial growth factor mRNA levels. In conclusion, ST attenuates cardiac remodeling after MI, at least in part, through improving coronary vascularity in the noninfarcted myocardium. Repeated ST might serve as a novel noninvasive therapy for patients with MI.
- Subjects :
- Actins metabolism
Analysis of Variance
Animals
Atrial Natriuretic Factor genetics
Cardiomegaly physiopathology
Cardiomegaly prevention & control
Chi-Square Distribution
Coronary Vessels metabolism
Coronary Vessels pathology
Disease Models, Animal
Gene Expression Regulation
Hemodynamics
Male
Myocardial Infarction diagnostic imaging
Myocardial Infarction genetics
Myocardial Infarction metabolism
Myocardial Infarction physiopathology
Myocardium metabolism
Nitric Oxide Synthase Type III genetics
Platelet Endothelial Cell Adhesion Molecule-1 metabolism
RNA, Messenger metabolism
Rats
Rats, Wistar
Time Factors
Ultrasonography
Vascular Endothelial Growth Factor A genetics
Ventricular Function, Left
Ventricular Pressure
Coronary Vessels physiopathology
Myocardial Infarction therapy
Myocardium pathology
Neovascularization, Physiologic
Steam Bath
Ventricular Remodeling
Subjects
Details
- Language :
- English
- ISSN :
- 1522-1539
- Volume :
- 301
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- American journal of physiology. Heart and circulatory physiology
- Publication Type :
- Academic Journal
- Accession number :
- 21622828
- Full Text :
- https://doi.org/10.1152/ajpheart.00103.2011