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Identification of ostruthin from Peucedanum ostruthium rhizomes as an inhibitor of vascular smooth muscle cell proliferation.
- Source :
-
Journal of natural products [J Nat Prod] 2011 Jun 24; Vol. 74 (6), pp. 1513-6. Date of Electronic Publication: 2011 May 31. - Publication Year :
- 2011
-
Abstract
- Inhibition of vascular smooth muscle cell (VSMC) proliferation is of substantial interest in combating cardiovascular disease. A dichloromethane extract from the rhizomes of Peucedanum ostruthium, a traditionally used Austrian medicinal plant with anti-inflammatory properties, was examined for a putative antiproliferative activity in rat aortic VSMC. This extract inhibited serum (10%)-induced VSMC proliferation concentration dependently. Further identification and biological testing of its major constituents revealed that the coumarin ostruthin (7) is the major antiproliferative substance. In summary, a new bioactivity of P. ostruthium rhizomes is described, and 7 has been identified as the responsible compound.
- Subjects :
- Animals
Aorta, Thoracic cytology
Austria
Molecular Structure
Rats
Rats, Sprague-Dawley
Rhizome chemistry
Umbelliferones chemistry
Aorta, Thoracic drug effects
Apiaceae chemistry
Cell Proliferation drug effects
Muscle, Smooth, Vascular drug effects
Umbelliferones isolation & purification
Umbelliferones pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1520-6025
- Volume :
- 74
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 21627108
- Full Text :
- https://doi.org/10.1021/np200072a