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Production of 8-prenylnaringenin from isoxanthohumol through biotransformation by fungi cells.

Authors :
Fu ML
Wang W
Chen F
Dong YC
Liu XJ
Ni H
Chen QH
Source :
Journal of agricultural and food chemistry [J Agric Food Chem] 2011 Jul 13; Vol. 59 (13), pp. 7419-26. Date of Electronic Publication: 2011 Jun 10.
Publication Year :
2011

Abstract

8-Prenylnaringenin (8PN), which presents in hop, enjoys fame as the most potential phytoestrogen. Although a number of health effects are attributed to 8PN, few reports are available about the production of it. In this work, screening of fungi to efficiently transform isoxanthohumol (IXN) into 8PN was designed. The biotransformation of IXN was significantly observed in Eupenicillium javanicum, Cunninghamella blakesleana, and Ceriporiopsis subvermispora under five kinds of transformation conditions. As a comparative result of IXN transformation, E. javanicum was the optimal biocatalyst to produce 8PN. Transformation caused by growing precultured fungal mycelia, a process designated as G2, was a favorable condition for IXN transformation in view of the yield of 8PN. The possible transformation pathway of 8PN bioproduction is postulated in this work. The construction of fungus and transformation mode derived from the current work is viable and an alternative procedure for 8PN formation.

Details

Language :
English
ISSN :
1520-5118
Volume :
59
Issue :
13
Database :
MEDLINE
Journal :
Journal of agricultural and food chemistry
Publication Type :
Academic Journal
Accession number :
21634799
Full Text :
https://doi.org/10.1021/jf2011722