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Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of tertiary alcohol-bearing piperidines.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2011 Jul 01; Vol. 21 (13), pp. 3976-81. Date of Electronic Publication: 2011 May 14. - Publication Year :
- 2011
-
Abstract
- The design and optimization of a novel series of renin inhibitor is described herein. Strategically, by committing the necessary resources to the development of synthetic sequences and scaffolds that were most amenable for late stage structural diversification, even as the focus of the SAR campaign moved from one end of the molecule to another, highly potent renin inhibitors could be rapidly identified and profiled.<br /> (Copyright © 2011 Elsevier Ltd. All rights reserved.)
- Subjects :
- Alcohols chemistry
Alcohols therapeutic use
Animals
Antihypertensive Agents chemistry
Molecular Structure
Piperidines chemistry
Piperidines therapeutic use
Rats
Renin chemistry
Structure-Activity Relationship
Alcohols chemical synthesis
Antihypertensive Agents chemical synthesis
Antihypertensive Agents therapeutic use
Drug Design
Hypertension drug therapy
Piperidines chemical synthesis
Renin antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 21
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 21641209
- Full Text :
- https://doi.org/10.1016/j.bmcl.2011.05.014