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Birth prevalence rates of newborn screening disorders in relation to screening practices in the United States.
- Source :
-
The Journal of pediatrics [J Pediatr] 2011 Oct; Vol. 159 (4), pp. 555-60. Date of Electronic Publication: 2011 Jun 08. - Publication Year :
- 2011
-
Abstract
- Objective: To examine the associations between the first-tier-screening laboratory methods and criteria and the birth prevalence of congenital adrenal hyperplasia (CAH), phenylketonuria (PKU), and the sickle hemoglobinopathies occurring in the United States between 1991 and 2000.<br />Study Design: By using validated data from the National Newborn Screening and Genetics Resource Center, we fit Poisson regression models with laboratory methods and criteria used in every year for each state for each disorder. We also examined whether there was an overall change in birth prevalence over the decade and whether there was an effect resulting from obligatory second screenings.<br />Results: There were no associations among any of the factors and the birth prevalence of PKU in this decade. Use of the enzyme-linked immunosorbent assay was more likely than any other laboratory method to identify cases of CAH (OR 1.16; 95% CI 1.04-1.30), but no other factors were associated with this disorder. None of the factors examined were associated with the birth prevalence rates of any of the sickle hemoglobinopathies.<br />Conclusion: There were no substantial changes in the birth prevalence rates of PKU, CAH, or the sickle hemoglobinopathies over the study period despite rapid changes in technology.<br /> (Copyright © 2011 Mosby, Inc. All rights reserved.)
- Subjects :
- Chromatography, High Pressure Liquid
Enzyme-Linked Immunosorbent Assay
Fluoroimmunoassay
Humans
Infant, Newborn
Neonatal Screening methods
Prevalence
Tandem Mass Spectrometry
United States
Adrenal Hyperplasia, Congenital epidemiology
Anemia, Sickle Cell epidemiology
Phenylketonurias epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6833
- Volume :
- 159
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The Journal of pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 21641615
- Full Text :
- https://doi.org/10.1016/j.jpeds.2011.04.011