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Characteristics of patients with respiratory allergy in France and factors influencing immunotherapy prescription: a prospective observational study (REALIS).
- Source :
-
International journal of immunopathology and pharmacology [Int J Immunopathol Pharmacol] 2011 Apr-Jun; Vol. 24 (2), pp. 387-400. - Publication Year :
- 2011
-
Abstract
- To describe the sensitization profile of respiratory allergies in France, identifying factors influencing the prescription of allergen immunotherapy (AIT) [Transversal phase (T)], and assess treatment efficacy, tolerability, compliance and satisfaction [Longitudinal phase (L)]. French allergists (600) and pneumo-allergists (600) were offered participation and asked to recruit the first 20 new patients with allergic rhinitis (AR) and/or asthma, consulting for a first time allergy check-up with skin prick-test (T), and 5 patients sensitized to pollens (skin test and/or specific IgE) for whom SLIT with pollens was prescribed (L). In the T phase, 2,714 patients were recruited by 169 specialists, mostly allergists (76.5%). The majority (98%) suffered from AR, alone (57.7%) or with asthma (40.3%) and 80.3% suffered from moderate-to-severe rhinitis, mostly persistent (65.8%). Asthma, when present, was mostly intermittent (63.7%) or mild persistent (20.1%). Sensitization to house dust mites was the most common (64.5%), followed by grass pollens (61.5%), tree pollens (41.6%) and cat danders (30.5%). Poly-sensitization was seen in 73.6% of patients. AIT, mostly sublingual, was recommended in 55.6% of the patients, mostly (78.1%) because of insufficient control with symptomatic treatments. The overall impact of symptoms on QOL, positive skin test to grass pollens, ocular pruritus and/or nasal obstruction and moderate-to-severe rhinitis were significant predictors of SLIT prescription. Poly-sensitization or concomitant asthma were not seen as deterrents. Most patients consulting a specialist for allergy testing suffer from moderate-to-severe rhinitis. Treatment in current practice includes immunotherapy in half of the patients, and follows ARIA recommendations.
- Subjects :
- Adolescent
Adult
Aged
Antigens adverse effects
Antigens immunology
Asthma diagnosis
Asthma epidemiology
Asthma immunology
Child
Child, Preschool
Female
France epidemiology
Guideline Adherence
Humans
Male
Medication Adherence
Middle Aged
Patient Satisfaction
Practice Guidelines as Topic
Prospective Studies
Rhinitis, Allergic, Perennial diagnosis
Rhinitis, Allergic, Perennial epidemiology
Rhinitis, Allergic, Perennial immunology
Rhinitis, Allergic, Seasonal diagnosis
Rhinitis, Allergic, Seasonal epidemiology
Rhinitis, Allergic, Seasonal immunology
Severity of Illness Index
Skin Tests
Time Factors
Treatment Outcome
Young Adult
Antigens therapeutic use
Asthma therapy
Desensitization, Immunologic adverse effects
Practice Patterns, Physicians' statistics & numerical data
Rhinitis, Allergic, Perennial therapy
Rhinitis, Allergic, Seasonal therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0394-6320
- Volume :
- 24
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- International journal of immunopathology and pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 21658313
- Full Text :
- https://doi.org/10.1177/039463201102400212