Back to Search
Start Over
Differential impairment of vascularization and angiogenesis in bisphosphonate-associated osteonecrosis of the jaw-related mucoperiosteal tissue.
- Source :
-
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics [Oral Surg Oral Med Oral Pathol Oral Radiol Endod] 2011 Aug; Vol. 112 (2), pp. 216-21. Date of Electronic Publication: 2011 Jun 12. - Publication Year :
- 2011
-
Abstract
- Objectives: Impaired vascularization in the etiopathology of aminobisphosphonate-associated osteonecrosis of the jaw (BONJ) is assumed, but evidence is lacking. This immunohistochemical study differentiated vascularization and angiogenesis in BONJ-adjacent mucoperiosteal tissue.<br />Study Design: Twenty BONJ (after zoledronate treatment) and 20 control mucoperiosteal tissue samples were processed with an autostaining-based alkaline phosphatase-antialkaline phosphatase staining kit. Vascularization was assessed by CD31 staining and angiogenesis-related neovessels by CD105 staining. The ratio of stained capillary area to total area of visible field was assessed. Statistics included Bonferroni adjustment.<br />Results: CD31-stained microvessels were detected in each section and CD105-stained neovessels in each control. BONJ-adjacent mucoperiosteal tissue showed significantly fewer CD105-positive vessels in capillary areas (P < .05) than control samples. CD31-stained capillary area was not significantly reduced in mucoperiosteal BONJ-samples.<br />Conclusions: Angiogenesis is impaired in BONJ-related mucoperiosteal tissue, but vascularization remains unaffected. Vessel remodeling and neovessel formation is delayed in BONJ, resulting in impaired tissue regeneration of bisphosphonate-exposed oral mucosa.<br /> (Copyright © 2011 Mosby, Inc. All rights reserved.)
- Subjects :
- Alkaline Phosphatase analysis
Alveolar Process drug effects
Antigens, CD analysis
Capillaries drug effects
Capillaries pathology
Coloring Agents
Connective Tissue blood supply
Connective Tissue drug effects
Endoglin
Endothelial Cells drug effects
Endothelial Cells pathology
Endothelium, Vascular drug effects
Endothelium, Vascular pathology
Humans
Image Processing, Computer-Assisted methods
Imidazoles adverse effects
Immunohistochemistry
Jaw Diseases pathology
Mouth Mucosa blood supply
Mouth Mucosa drug effects
Osteonecrosis pathology
Periosteum blood supply
Periosteum drug effects
Platelet Endothelial Cell Adhesion Molecule-1 analysis
Receptors, Cell Surface analysis
Zoledronic Acid
Alveolar Process blood supply
Bone Density Conservation Agents adverse effects
Diphosphonates adverse effects
Jaw Diseases chemically induced
Neovascularization, Physiologic drug effects
Osteonecrosis chemically induced
Subjects
Details
- Language :
- English
- ISSN :
- 1528-395X
- Volume :
- 112
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
- Publication Type :
- Academic Journal
- Accession number :
- 21664154
- Full Text :
- https://doi.org/10.1016/j.tripleo.2011.02.028