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Clinical study protocol for the ARCH project - computational modeling for improvement of outcome after vascular access creation.
- Source :
-
The journal of vascular access [J Vasc Access] 2011 Oct-Dec; Vol. 12 (4), pp. 369-76. - Publication Year :
- 2011
-
Abstract
- Despite clinical guidelines and the possibility of diagnostic vascular imaging, creation and maintenance of a vascular access (VA) remains problematic: avoiding short- and long-term VA dysfunction is challenging. Although prognostic factors for VA dysfunction have been identified in previous studies, their potential interplay at a systemic level is disregarded. Consideration of multiple prognostic patient specific factors and their complex interaction using dedicated computational modeling tools might improve outcome after VA creation by enabling a better selection of VA configuration. These computational modeling tools are developed and validated in the ARCH project: a joint initiative of four medical centers and three industrial partners (FP7-ICT-224390). This paper reports the rationale behind computational modeling and presents the clinical study protocol designed for calibrating and validating these modeling tools. The clinical study is based on the pre-operative collection of structural and functional data at a vascular level, as well as a VA functional evaluation during the follow-up period. The strategy adopted to perform the study and for data collection is also described here.
- Subjects :
- Angiography, Digital Subtraction
Europe
Hemodynamics
Humans
Kidney Failure, Chronic diagnosis
Kidney Failure, Chronic physiopathology
Magnetic Resonance Angiography
Predictive Value of Tests
Prospective Studies
Regional Blood Flow
Reproducibility of Results
Risk Assessment
Risk Factors
Tomography, X-Ray Computed
Ultrasonography, Doppler, Duplex
Arteriovenous Shunt, Surgical adverse effects
Computer Simulation
Image Processing, Computer-Assisted
Kidney Failure, Chronic therapy
Models, Cardiovascular
Renal Dialysis
Research Design
Upper Extremity blood supply
Subjects
Details
- Language :
- English
- ISSN :
- 1724-6032
- Volume :
- 12
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The journal of vascular access
- Publication Type :
- Academic Journal
- Accession number :
- 21667457
- Full Text :
- https://doi.org/10.5301/JVA.2011.8382