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[Combination chemotherapy including cisplatinum, vindesine and mitomycin C for non-small cell lung cancer].
- Source :
-
Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho] 1990 Aug; Vol. 17 (8 Pt 1), pp. 1455-60. - Publication Year :
- 1990
-
Abstract
- Thirty-five patients with non-small cell lung cancer (adenocarcinoma: 15, squamous cell: 15, large cell: 5, Stage I: 3, II: 1, IIIA: 8, IIIB: 5, IV: 18) were treated with combination chemotherapy, CDDP 80 mg/m2 day 1, VDS 3 mg/m2 days 1 & 8, and MMC 8 mg/m2 day 1. This regimen was repeated two times at intervals of four weeks. Sixteen partial responses were observed (response rate of 45.7%), and the median duration of survival for responders was 12.6 +/- 7.5 months and for nonresponders 10.1 +/- 4.8 months. Statistically there was no difference between them, but a survival from the onset of therapy of responders was significantly better (p less than 0.05) than that of non-responders. Toxicity was tolerable with myelosuppression, chemotherapy-induced nausea and vomiting.
- Subjects :
- Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols adverse effects
Carcinoma, Non-Small-Cell Lung mortality
Cisplatin administration & dosage
Cisplatin adverse effects
Drug Evaluation
Female
Humans
Leukopenia chemically induced
Lung Neoplasms mortality
Male
Middle Aged
Mitomycin
Mitomycins administration & dosage
Mitomycins adverse effects
Remission Induction
Survival Rate
Thrombocytopenia chemically induced
Vindesine administration & dosage
Vindesine adverse effects
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Carcinoma, Non-Small-Cell Lung drug therapy
Lung Neoplasms drug therapy
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0385-0684
- Volume :
- 17
- Issue :
- 8 Pt 1
- Database :
- MEDLINE
- Journal :
- Gan to kagaku ryoho. Cancer & chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 2167632